I. Historical Perspectives of Tachykinins. - 1 History of Tachykinin Peptides 1. - 2 History of Tachykinin Receptors 23. - II. Characterization of Tachykinin Receptors. - 3 Biochemical Methods and Assays 39. - 4 Agonist and Antagonist Receptor Binding. - 5 Comparative Distribution of Receptor Types in the Mammalian Brain 101. - 6 Autoradiographic Localization of Receptors in Peripheral Tissues 125. - 7 Molecular Biology of Receptors: Structures Expressionand Regulatory Mechanisms 165. - 8 Characterization of the NKl Receptor Using Photoaffinity Probes 219. - 9 Modeling of G-Protein-Coupled Receptors: Application to the NK1Tachykinin Receptor 237. - III. Mechanisms of Tachykinin Receptor Action. - 10 Receptors and the Inositol PhosphateCalcium Signaling System 257. - 11 Signal Transduction Mechanisms of Tachykinin Effects on Ion Channels 285. - IV. Tachykinin Receptor Function. - 12 StructureActivity Relationships of Agonist and Antagonist Ligands 329. - 13 Pharmacological Characterization of Receptor Types 367. - 14 Evidence for Receptor Subtypes/Species Variants of Receptors. 395. - 15 Role of Receptors in Nociception 471. - 16 Pharmacological Characterization of Receptors in the Spinal Cord of the Newborn Rat 499. - 17Receptor Function in the Periphery 515. - 18 Receptor Involvement in Pathology and Disease 581. - V. Summary and Future Perspectives. - 19 Summary Thoughts and Future Perspectives 611. Language: English